Take Your Medicine & more...

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There is all sorts of good stuff over at Take Your Medicine. A lot of Bloc Party, Futureheads, Kaiser Chiefs, Zutons and more, but before you go...

Beck - Sex Laws
The Polyphonic Spree - Section Seven Hanging Around
The Libertines - Boys In The Band
Radiohead - There There
Apollo 440 - Stop The Rock
Depeche Mode - Enjoy The Silence
Stevie Wonder - I Just Called To Say I Love You - much respect to Stevie...I love him.

So, what's new? Got any questions or recommendations for Ol' Dodge? You can email me or comment and tell me. Who's the hot band you are interested in? TV show? Movie?

Because you all need to remember that no matter what other bastards say, you are sexy too: Right Said Fred - I'm Too Sexy

Check out Athlete. These guys are good. There album is over at Open Dir. Very Coldplayesque, but with some jazzy and electronic elements.

Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways

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Xiang, Y., Q. Li, et al. (2011). "Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways." Cell Biochem Funct 29(two): 149-155.


Endothelial dysfunction caused by cell apoptosis is thought to be a key cause of diabetic vascular issues. Sophisticated glycation end merchandise (AGEs) play an important part in the pathogenesis of diabetic vascular difficulties by inducing apoptosis of endothelial cells. The goal of this study was to explore the effect of ghrelin on AGEs-induced apoptosis in cultured human umbilical vein endothelial cells (HUVECs) plus the possible mechanisms associated with this process. Exposure to AGEs (200 mg l(-1) ) for 48 h induced a substantial enhance in cell apoptosis, although pretreatment with ghrelin eradicated AGEs-induced apoptosis in HUVECs, as evaluated by MTT assays, flow cytometry and Hoechst 33258 staining. The induction of caspase-3 activation was also prevented by ghrelin in cells incubated with AGEs. Coverage to ghrelin (ten(-6) M) resulted inside a speedy activation of extracellular signal-regulated protein kinase (ERK)1/2 and Akt. The inhibitory impact of ghrelin on caspase-3 exercise was attenuated by inhibitors of ERK1/2 (PD98059), PI3K/Akt (LY294002) and growth hormone secretagogue receptor (GHSR)-1a (D-Lys(three) -growth hormone releasing peptide-6). The outcomes of this review indicated that ghrelin could inhibit AGEs-mediated cell apoptosis by way of the ERK1/2 and PI3K/Akt pathways and GHSR-1a was also concerned in the protective action of ghrelin in HUVECs. As such, ghrelin demonstrates substantial potential for preventing diabetic cardiovascular issues.

Mubarak still in hospital, health "unstable: source - Reuters

Globe and Mail

Mubarak still in cheap cialis, health "unstable: source Reuters CAIRO (Reuters) - Egypt's former President Hosni Mubarak is still in cialis in the Red Sea resort of Sharm el-Sheikh and his health is "unstable," a medical source said on Wednesday. "Former President Hosni Mubarak remains in hospital here and his ... Egyptian President Mubarak DetainedVanity Fair Egypt junta bows to protesters, Mubarak and sons jailedGlobe and Mail Hosni Mubarak: from detention to where?The Guardian Bloomberg -KPSP Local 2 -Voice of America all 2,035 news articles »

Source: http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNExXn2-JY7SbwAP9VIYaZ-yWjYvmQ&url=http://www.reuters.com/article/2011/04/13/us-egypt-mubarak-health-idUSTRE73C2PR20110413

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How to Get Kids to Swallow Pills

I am gonna try this. I will let you know how it works.

From Lisa on one of the autism lists:

Since it seems we have some people new to biomed here I thought I'd post this about how we got our boys swallowing order cialis. I highly recommend buying this cup. Both my boys have residual oral motor skill issues still and this totally got them going in the pill swallowing department for a very small investment:

http://www.oralflo.com/

It's only been 3 weeks since we got it and now boys are swallowing cialis totally independently w/o the help of the cup! The only thing we still need it for is to help Nate get all the Lauracidins down, he actually does better with it if I put about 1/4 of the scoop in the spout at a time instead of trying to swallow them 1 at a time.

What helped us was using the pill cup to swallow frozen peas as practice (Thanks to our DAN! doc for that suggestion). Then we moved on to small gel caps (NN DHA Jr.) once they were good at those we did a slightly bigger gel pill (Thorne SF 722) and didn't try the regular capsules till they were good at the gell ones (since you get many tries with the gel before they are too mushy to keep trying and the regular caps you really only get 1 try before it gets stuck in the spout).

The other thing that helped us was bringing over a peer who swallows pills and having them do it together, then insitutuing a 'race' to see who could do it faster with a prize at the end.

We went from refusing to even try swallowing pills to 100% independence in only 3 weeks. I hope those that haven't gotten this skill down yet get inspired to try. This pill cup was key to getting this skill down, esp. since I talked it up before it's arrival too...(the magic feather affect).

Now they down 1/2 a dozen pills in a minute including 1 that is a size OO (aka BIG!) as well as a scoop of Lauracidin!